Overview of Research

INSPIRE Therapy
Destroying inoperable tumors using pulsed electric fields

Electrical Cell Sorting
Identifying and isolating rare cells from blood to detect cancer before it becomes symptomatic

Developing new materials from the bottom up using biology to fabricate  nano-structures and electric fields to manipulate the nano-archetecture

Therapeutic Imaging
Developing new ways to monitor electric field mediated therapies
Imaging deeper into tissue with higher contrast than possible using light or acoustics
News
The lab has moved the UNC-NCSU Joint Department of Biomedical Engineering!!
New opening - Post-doctoral scholar: Interested BME / Biology / Electrical Engineering candidates should apply via email
New opening - Laboratory Technician: Interested candidates with a BS in Biology or BME should apply via email

Our patent has issued: Methods for enhancing and modulating reversible and irreversible electroporation lesions by manipulating pulse waveforms
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The lab has been awarded the UNC Lineberger Comprehensive Cancer Center: Developmental Award for our proposal "INSPIRE Immunity: Systemic Cancer Therapy using Immunostimulating Pulsed Electric Fields" This will enable our laboratory to investigate techniques for stimulating an anti-tumor immune response against metastatic disease.
"Temperature Dependence of High Frequency Irreversible Electroporation Evaluated in a 3D Tumor Model" has been accepted for publication in the Annals of Biomedical Engineering
[In Press] [test]

"Algorithmically Controlled Electroporation: A Technique for Closed Loop Temperature Regulated Pulsed Electric Field Cancer Ablation" has been accepted for publication in the IEEE Transactions on Biomedical Engineering
[In Press] [test]

The lab has been awarded the NCSU Chancellor's Innovation Fund Award for our proposal "A Preclinical Safety Study of Electro-Thermal Therapy"
This will enable our laboratory to investigate the safety and efficacy of newly developed cancer therapies in clinically relevant models.
"Bipolar High-Frequency Pulses Using A Single Insertion Device Enable Simplified, Non-Thermal Tissue Ablation" has been accepted for publication in the IEEE Transactions on Biomedical Engineering
[In Press] [test]
"High Frequency Irreversible Electroporation Using 5000V Waveforms to Create Reproducible 2 and 4 centimeter Ablation Zones" has been accepted for publication in the Journal of Vascular and Interventional Radiology (JVIR)
[In Press] [test]
https://sites.google.com/site/mbsano/home/Gel%20Convolution%202.jpg?attredirects=0

"Burst and Continuous High Frequency Irreversible Electroporation Protocols Evaluated in a Three Dimensional Tumor Model" has been accepted for publication in Physics in Medicine and Biology
[Download] [Supplemental Material] [View Online]
https://sites.google.com/site/mbsano/home/SingleInsertionDevices.jpg?attredirects=0

"Optimization of a Single Insertion Electrode Array for the Creation of Clinically Relevant Ablations Using High-Frequency Irreversible Electroporation" has been accepted for publication in Computers in Biology and Medicine
[Download] [Supplemental Material]

"Reduction of Muscle Contractions during Irreversible Electroporation Therapy Using High Frequency Bursts of Alternating Polarity Pulses" has been accepted for publication in the Journal of Vascular and Interventional Radiology (JVIR)
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"Treatment of Cancer In Vitro Using Radiation and High-Frequency Bursts of Submicrosecond Electrical Pulses" has been accepted for publication in the IEEE Transactions on Biomedical Engineering
[Download] [View Online] [Supplemental Material]

"A Comprehensive Characterization of Parameters Affecting High-Frequency Irreversible Electroporation Lesions" has been accepted for publication in the Annals of Biomedical Engineering
[Download] [View Online] [Supplemental Material]
Electroporation of cells in-vitro

 "Asymmetric Waveforms Decrease Lethal Thresholds in High Frequency Irreversible Electroporation Therapies" has been accepted for publication in Nature Scientific Reports
[Download] [View Online] [Supplemental Materials]
 Creation of spherical ablations using a single electrode and grounding pad "Production of Spherical Ablations using Non-Thermal Irreversible Electroporation - A Laboratory Investigation Using a Single Electrode and Grounding Pad" has been accepted for publication in the Journal of Vascular and Interventional Radiology  (JVIR) 
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Selective Ablation of Cancer Cells
 "Targeted Cellular Ablation Based On The Morphology of Malignant Cells" has been accepted for publication in Nature Scientific Reports
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INSPIRE Therapy
 "Bursts of Microsecond Pulses Inhibit Tumor Growth" has been accepted for publication in Nature Scientific Reports
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